This web page was produced for Genetics 564, an undergraduate course at UW-Madison
RNAi analysis
Examining the response of altered or absent PKD1 in other organisms can provide information about the development of polycystic kidney disease in humans. Each organism will experience different outcomes when PKD1 is altered. Subsequent studies may yield information about the importance of each of these observed responses in the development of polycystic kidney disease.
Analysis
The phenotypes of PKD1 and PKD2 mutations in mice and rats closely mirror the phenotypes within humans. The phenotype in C. elegans, in contrast, is starkly different. This probably reflects the evolutionary divergence between these species. Possibly, the mating behavior of males requires cation channel activity that is similar in the cation channel activity of PKD1 homologues in other species, although towards different purposes.
References
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Site created by: Elizabeth Roeske Last updated: 5.12.2014 University of Wisconsin-Madison: Genetics 564 |